leukemia symptoms : Clinical Features in Rai & Binet Staging
Lymphocytosis = high numbers of lymphocytes
Lymphadenopathy = lymphatic disease
Hepatomegaly = enlarged liver
Splenomegaly = enlarged spleen
There are a few more types and subtypes of chronic leukemia, the most notable of which are hairy cell leukemia, prolymphocytic leukemia, T-cell chronic lymphocytic leukemia, and chronic myelomonocytic leukemia.
Hairy cell leukemia (HCL), like CLL, is a slow-growing lymphocytic cancer. It is distinguished by its appearance under the microscope, because the lymphocytes have many fine, "hairy" projections from their surfaces. HCL is typically a disease of middle-aged males. Most individuals report nonspecific symptoms that are partially caused by anemia. Yet HCL differs from CLL with respect management.
Both prolymphocytic leukemia (PLL) and T-cell chronic lymphocytic leukemia (T-CLL; also known as large granular lymphocyte leukemia, or LGL) are unusual forms of CLL. They are very rare, and account for only about 1% of all CLL cases. PLL, like CLL, is mostly seen in men. More than half of the cells in PLL are prolymphocytes, which are larger than CLL cells and have less condensed genetic material. T-CLL results from the reproduction of cells that resemble normal large granular lymphocytes. PLL and T-CLL are more aggressive in nature than other forms of CLL, and they are less likely to respond to treatment.
There is some dispute about the categorization of chronic myelomonocytic leukemia (CMML). Some groups consider CMML to be a "pre-leukemia," or "myelodysplastic syndrome," rather than a malignant disorder. It is a disease that is found in older individuals. Patients may be asymptomatic (without symptoms) and be diagnosed accidentally, or they may have symptoms of tiredness, bruising and/or abdominal discomfort from an enlarged spleen. CMML may be inactive, or it may progress slowly over months and years. CMML eventually transforms into an acute, usually fatal form of leukemia.
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Lymphadenopathy = lymphatic disease
Hepatomegaly = enlarged liver
Splenomegaly = enlarged spleen
There are a few more types and subtypes of chronic leukemia, the most notable of which are hairy cell leukemia, prolymphocytic leukemia, T-cell chronic lymphocytic leukemia, and chronic myelomonocytic leukemia.
Hairy cell leukemia (HCL), like CLL, is a slow-growing lymphocytic cancer. It is distinguished by its appearance under the microscope, because the lymphocytes have many fine, "hairy" projections from their surfaces. HCL is typically a disease of middle-aged males. Most individuals report nonspecific symptoms that are partially caused by anemia. Yet HCL differs from CLL with respect management.
Both prolymphocytic leukemia (PLL) and T-cell chronic lymphocytic leukemia (T-CLL; also known as large granular lymphocyte leukemia, or LGL) are unusual forms of CLL. They are very rare, and account for only about 1% of all CLL cases. PLL, like CLL, is mostly seen in men. More than half of the cells in PLL are prolymphocytes, which are larger than CLL cells and have less condensed genetic material. T-CLL results from the reproduction of cells that resemble normal large granular lymphocytes. PLL and T-CLL are more aggressive in nature than other forms of CLL, and they are less likely to respond to treatment.
There is some dispute about the categorization of chronic myelomonocytic leukemia (CMML). Some groups consider CMML to be a "pre-leukemia," or "myelodysplastic syndrome," rather than a malignant disorder. It is a disease that is found in older individuals. Patients may be asymptomatic (without symptoms) and be diagnosed accidentally, or they may have symptoms of tiredness, bruising and/or abdominal discomfort from an enlarged spleen. CMML may be inactive, or it may progress slowly over months and years. CMML eventually transforms into an acute, usually fatal form of leukemia.
by Healthcommunities.com, Inc. All rights reserved.
